Anthem: Avastin Payer Policy

Created by C. Denise Burrell, Modified on Wed, 8 Jan at 1:51 PM by C. Denise Burrell

Anthem: Avastin Payer Policy (Beta Access)


HCPCS Code(s):C9257 Injection, bevacizumab, 0.25 mg , Avastin
J9035 Injection, bevacizumab, 10 mg 
  • When specified as Avastin intravitreal 
Precertification Required?
  • Not Required in specific markets for ocular indications (e.g., AR, CA, DC, GA, IN, IA, KY, etc.).
  • Required for certain markets like FL (Click Here for Full Policy)
Step Therapy Required?

✅ Yes  (Click Here for Full Policy)

Provider Fax Form:✅ Available in SamaCare
FDA Indications:

Avastin is not FDA-approved for ophthalmic use. However, it is widely used for the following off-label indications:

  1. Neovascular (wet) age-related macular degeneration (AMD)
  2. Diabetic macular edema (DME)
  3. Proliferative or moderate to severe non-proliferative diabetic retinopathy
  4. Macular edema from central and branch retinal vein occlusion
  5. Neovascular glaucoma
  6. Choroidal neovascularization associated with conditions such as myopic degeneration, angioid streaks, choroiditis, trauma, or pseudoxanthoma elasticum
  7. Radiation retinopathy
  8. Retinopathy of prematurity
Recommended Dosage:
  • 1.25 mg per eye – Each eye may be treated as frequently as every 4 weeks.


Note:  Avastin is considered a preferred agent.


Other Pertinent Information

  • Avastin is often obtained from compounding pharmacies for ophthalmic use.
  • FDA warnings emphasize using products from accredited compounding pharmacies to avoid contamination risks.


  • Quantity Limits:

    • 1.25 mg per eye – Each eye may be treated as frequently as every 4 weeks


  • Exclusion(s):
    • All other indications not explicitly listed are considered not medically necessary

Initial Approval Criteria

Authorization for 12 months may be granted if the member has a diagnosis of:

  1. Neovascular (wet) age-related macular degeneration (AMD)
  2. Diabetic macular edema (DME)
  3. Proliferative or moderate to severe non-proliferative diabetic retinopathy
  4. Macular edema from central or branch retinal vein occlusion
  5. Neovascular glaucoma
  6. Choroidal neovascularization due to myopic degeneration or other causes
  7. Radiation retinopathy
  8. Retinopathy of prematurity

Continuation Criteria

Authorization for 12 months may be granted if:

  1. The member is currently receiving therapy with Avastin.
  2. There is documentation of positive clinical response to therapy.



Sources:

https://www.anthem.com/ms/pharmacyinformation/VEGF.pdf

Additional Reources:

Medical Specialty Precertification Drug List: https://file.anthem.com/06347MUPENABS.pdf

Medical Step Therapy Drug List: https://file.anthem.com/A02605ANPENABS.pdf

Site of Care Drug List: https://file.anthem.com/06346MUPENABS.pdf


⚠️ Disclaimer: This article is a policy summary and does not guarantee coverage or approval. 

Policies may vary based on plan, payer-specific rules, state or regional requirements, benefit structure, formulary placement, and patient-specific considerations like diagnosis or clinical history. Always review the full policy and confirm details directly with the payer to ensure compliance. 


 

We're here to guide you through your prior authorization quest!





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